Glucophage 500 | Uses, Dosage, Price, Substitutes | ePharma
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Glucophage 500mg Tablet 10pcs

Generic: Metformin Hydrochloride

Type: Tablet

Pack Size: 10 Pcs

Glucophage is an oral diabetes medicine that helps control blood sugar levels. Glucophage is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.


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Discount Price: ৳ 275.5
MRP: ৳ 290 5% Off

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✅ Description:

  • Treats type 2 diabetes (non-insulin-dependent) when diet and exercise are insufficient.
  • Particularly effective for overweight patients.

Do Not Take If You Have:

  • Allergy to metformin hydrochloride or any of its ingredients.
  • Liver problems.
  • Severely reduced kidney function.
  • Uncontrolled diabetes with severe symptoms.
  • Severe infections affect the lungs, bronchial system, or kidneys.
  • Acute heart failure, recent heart attack, severe circulation problems, or breathing difficulties.
  • High alcohol consumption.

Risk of Lactic Acidosis:

  • A rare but serious side effect, especially if kidneys are not working properly, or if you have uncontrolled diabetes, serious infections, liver problems, or are dehydrated.
  • Stop taking metformin and contact a doctor immediately if you experience symptoms.

Symptoms of Lactic Acidosis:

  • Vomiting.
  • Stomach ache.
  • Muscle cramps.
  • Severe tiredness.
  • Difficulty breathing.
  • Reduced body temperature and heartbeat.

Risk of Hypoglycemia:

  • Can occur if taken with other diabetes medications.
  • Symptoms include weakness, dizziness, increased sweating, fast heartbeat, vision disorders, and difficulty concentrating. Consuming sugar helps alleviate these symptoms.

Inform your doctor if you use:

  • Diuretics.
  • NSAIDs (pain and inflammation).
  • High blood pressure medications.
  • Beta-2 agonists (e.g., salbutamol for asthma).
  • Corticosteroids.
  • Other diabetes medications.

Safety Advices


Alcohol
UNSAFE

Unsafe to consume with Glucophage. Alcohol increases the risk of lactic acidosis.


Pregnancy
CONSULT YOUR DOCTOR

Generally considered safe if prescribed. Animal studies show low or no adverse effects; limited hu


Breastfeeding
SAFE IF PRESCRIBED

Probably safe if prescribed. Limited data suggests no significant risk to the baby.


Driving
CAUTION

Be cautious. Blood sugar levels that are too low or too high can impair your ability to drive.


Kidney
CAUTION

Use with caution. Dose adjustment may be needed. Not recommended for severe kidney disease. Regular kidney function tests are advised.


Liver
CAUTION

Use with caution. Dose adjustment may be needed. Generally started at a low dose in mild to moderate liver disease. Not recommended for severe liver disease.

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✔️ Uses of Glucophage 500mg Tablet
  • Type 2 Diabetes
  • Polycystic Ovary Syndrome (PCOS)
✔️ How does Glucophage 500mg Tablet work?

Glucophage is an anti-diabetic medication (biguanide) that:

  • Lowers glucose production in the liver.
  • Delays absorption of sugar from the intestines.
  • Increases the body's sensitivity to insulin.
✔️ Side Effects of Glucophage 500mg Tablet
  • Low blood sugar
  • Nausea
  • Upset stomach
  • Diarrhea
  • Unusual muscle pain
  • Feeling cold
  • Trouble breathing
  • Dizziness, light-headedness, tiredness, or weakness
  • Stomach pain, vomiting
  • Slow or irregular heart rate
✔️ Quick Suggestions:
  • You have been prescribed Glucophage 500 to control blood sugar levels and reduce the risk of diabetic complications such as heart attacks.
  • Less likely to cause weight gain and low blood sugar compared to other diabetes medications.
  • Monitor Blood Sugar regularly while taking Glucophage 500.
  • If you experience symptoms of lactic acidosis or vitamin B12 deficiency.
  • Essential for managing diabetes alongside Glucophage.
  • Not for children under 10 years old.
  • Glucophage XR is not for anyone under 18 years old.
✔️ Renal Dose Adjustments of Glucophage 500mg Tablet
  • Obtain eGFR before starting metformin.
    • eGFR < 30 mL/min/1.73 m²: Contraindicated.
    • eGFR 30-45 mL/min/1.73 m²: Not recommended to initiate treatment.
    • eGFR Monitoring: At least annually or more frequently for those at risk for renal impairment (e.g., elderly).
    • If eGFR falls below 45 mL/min/1.73 m²: Evaluate the risks and benefits of continuing therapy.
    • If eGFR falls below 30 mL/min/1.73 m²: Discontinue the drug.
✔️ Adult Dose for Type 2 Diabetes Mellitus:

Conventional Preparation:

  • Initial Dose: 500 mg twice daily (bid) or three times daily (tid), or 850 mg once or twice daily.
  • Titration: Increase gradually by 500 mg weekly.
  • Maintenance Dose: Up to 2000 mg daily.
  • Maximum Dose: 2550 mg per day.

Modified-Release Preparation:

  • Initial Dose: 500 mg once daily.
  • Titration: Increase in increments of 500 mg at intervals of at least one week.
  • Maximum Dose: 2000 mg once daily at night. If glycemic control is insufficient, divide the dose to give 1000 mg twice daily (bid).

Adult Dose for Polycystic Ovary Syndrome (PCOS):

  • Initial Dose: 500 mg once daily in the morning for one week.
  • Increase to: 500 mg twice daily for one week.
  • Maintenance Dose: 1.5-1.7 g/day in 2-3 divided doses.

Elderly:

  • Dosing: Initial and maintenance dosing should be conservative due to the increased risk of lactic acidosis.

Hepatic Impairment:

  • Caution: Avoid use due to the increased risk of lactic acidosis.

Child Dose for Type 2 Diabetes Mellitus (≥10 years old):

  • Initial Dose: 500 mg 1-2 times daily or 850 mg once daily.
  • Titration: Increase gradually to a maximum of 2000 mg daily in 2 or 3 divided doses at intervals of at least one week.
✔️ Administration
  • Take it as soon as possible. If it's almost time for your next dose, skip the missed dose. Do not double the dose.
  • Follow your doctor's prescription and instructions.
  • Typically taken with a meal.
  • Glucophage XR should be taken once daily with the evening meal.
  • Do not crush, chew, or break extended-release tablets; swallow them whole.
✔️ Before Taking Glucophage:

Do not use if you have:

  • Severe kidney disease
  • Metabolic acidosis or diabetic ketoacidosis
  • Allergies to metformin

Inform your doctor if you have:

  • Kidney disease
  • High ketone levels in blood or urine
  • Heart disease or congestive heart failure
  • Liver disease
  • Use insulin or other oral diabetes medications
✔️ Special considerations:
  • May need to stop temporarily before surgery or x-ray/CT scan with injected dye.
  • Risk of lactic acidosis, especially with severe infection, chronic alcoholism, or if over 65.
  • Possible increase in ovulation risk in premenopausal women, raising the chance of unintended pregnancy.
  • Should not be used during breastfeeding.
✔️ Pregnancy & Lactation
  • Important to control diabetes during pregnancy to avoid complications.
  • Consult your doctor if you become pregnant while taking Glucophage.
✔️ Precautions & Warnings
  • Avoid if you have severe kidney disease, metabolic acidosis, or diabetic ketoacidosis.
  • Temporary discontinuation may be necessary before certain medical procedures involving contrast dye.
  • Monitor for signs of lactic acidosis and seek emergency help if experiencing severe side effects like muscle pain, breathing difficulties, or extreme fatigue.
  • Prolonged use may lead to vitamin B12 deficiency; monitor for symptoms like fatigue, pale skin, shortness of breath, or headache.
✔️ Storage Conditions:

Store in a cool and dry place away from sunlight

Frequently Asked Questions (FAQ)

A: As a diabetic patient, you should avoid: Shopping when hungry, as this can lead to impulse buys of unhealthy, oil-fried foods. Cream soups, carrot juice, deep-fried vegetables, and vegetable curries with excess oil. White bread, potatoes, noodles, corn flakes, biryani, naan, and fried rice. Cheese, milkshakes, ice creams. Pork, beef, soft drinks, sugarcane juice, and sweetened health drinks and beverages.

A: A diabetes-friendly diet should: Be high in fiber and low in fat, with adequate protein, carbohydrates, vitamins, and minerals. Include boiled, steamed, or baked foods. Use edible oils like groundnut oil or olive oil in moderation. Maintain regular meal timings and include 2-3 healthy snacks between meals, such as soups and salads.

A: Metformin is typically used alongside a proper diet and exercise program. Single-drug therapy with metformin can be effective for pre-diabetes or at the early stages of diabetes. However, as diabetes progresses, insulin production may become insufficient, necessitating the addition of other antidiabetic medications to achieve optimal blood sugar control.

A: Before beginning treatment with metformin, it is essential to: Get screened for baseline Vitamin B12 levels, kidney, and liver function. Share your weight, body mass index (BMI), and baseline blood sugar levels with your doctor. Provide a complete medical and surgical history, and inform your doctor about any past or ongoing medications you are taking.
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Check our pricing section for Glucophage 500mg Tablet 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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